People with 3 independent genetic variants are 9 times more likely to get psoriasis.
A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.
In the Aug. 13 issue of PLoS Genetics, researchers in the U School of Medicine’s Department of Dermatology confirm that the presence of HLA-Cw*0602, a gene variation or allele on chromosome 6 found by numerous investigators to be associated with psoriasis, is the “major genetic determinant” of the disease, but that other nearby genetic variations also play an independent role in contributing to psoriasis.
